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Wile E. Coyote is a main character of many Looney Tunes cartoons along with Road Runner. He is the mentor and favorite teacher of Calamity Coyote. In the Looney Tunes shorts, he is seen trying to capture and eat the Road Runner, and on occasion, Bugs Bunny. With a couple of exceptions, he rarely speaks, communicating instead with written signs. When he is shown to speak, he calls himself "Wile E. Coyote, Super Genius" (and ironically mispronounces his own last name).

Wile E. is voiced by Joe Alaskey when he talks in Tiny Toon Adventures.

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